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Antigen processing and presentation
(Elsevier Inc, 2019-01)
Dendritic cells are at the center of immune responses. They are defined by their ability to sense the environment, take up and process antigen, migrate to secondary lymphoid organs, where they present antigens to the ...
Pulsing Dendritic Cells with Whole Tumor Cell Lysates
(Springer, 2014-03)
One of the strategies employed in immunotherapy for cancer is to use of ex vivo-generated dendritic cells (DC) pulsed with tumor antigens. Several approaches have been used to obtain and load tumor antigens in DC. One such ...
Galectin-8 Enhances T cell Response by Promotion of Antigen Internalization and Processing
(Cell Press, 2020-07)
Galectin-8 (Gal-8) is a mammalian lectin endowed with immunostimulatory ability. In the present work, we demonstrate that Gal-8-glycan interactions on the surface of antigen-presenting cells (APCs) promote antigen binding ...
Syngeneic B16-F1 cells are more efficient than allogeneic Cloudman cells as antigen source in DC-based vaccination in the B16-F1 murine melanoma model
(Elsevier, 2019-07)
A major obstacle to obtaining relevant results in cancer vaccination has been the lack of identification of immunogenic antigens. Dendritic cell (DC)-based cancer vaccines used preventively may afford protection against ...
Ex Vivo Loading of Autologous Dendritic Cells with Tumor Antigens
(Springer, 2014-02)
Ex vivo-generated antigen-loaded dendritic cells (DC) have been shown to be immunogenic in patients with cancer. Loading DC with autologous whole tumor antigens is a strategy to arm DC against tumor without human leukocyte ...
Antibody specific B-cell epitope predictions: Leveraging information from antibody-antigen protein complexes
(Frontiers Media S.A., 2019-02)
B-cells can neutralize pathogenic molecules by targeting them with extreme specificity using receptors secreted or expressed on their surface (antibodies). This is achieved via molecular interactions between the paratope ...
Identification of immediate early gene products of bovine herpes virus 1 (BHV-1) as dominant antigens recognized by CD8 T cells in immune cattle
(Society for General Microbiology, 2017-07)
In common with other herpes viruses, bovine herpes virus 1 (BHV-1) induces strong virus-specific CD8 T-cell responses. However, there is a paucity of information on the antigenic specificity of the responding T-cells. The ...
Exploring the role of antigen presenting cells in male genital tract
(Wiley Blackwell Publishing, Inc, 2018-12)
Antigen presenting cells (APCs) are a critical mediator between innate and adaptive immune response. APCs have diverse functions in physiological and pathological conditions, such as maintenance of tissue homoeostasis, ...
Interleukin-6 signalling mediates Galectin-8 co-stimulatory activity of antigen-specific CD4 T-cell response
(Wiley Blackwell Publishing, Inc, 2018-06)
Galectin-8 (Gal-8) is a mammalian lectin endowed with the ability to co-stimulate antigen-specific immune responses. We have previously demonstrated that bone-marrow-derived dendritic cells produce high levels of interleukin-6 ...